ANTI-LITHIATIC EFFECT OF LYCOPENE IN CHEMICALLY INDUCED NEPHROLITHIASIS IN RATS

Objective: The search for anti-calculi drugs from natural sources has been believed of greater importance. Hence, the present study explored effectiveness lycopene against experimentally induced nephrolithiasis. Methods: experimental lasted 28 days. Adult male Wistar rats were divided into six groups. Group I (Normal control) received drinking water. II (Disease 0.75% ethylene glycol and 1% ammonium chloride in water to induce III–V was treated with (50 mg/kg, 100 200 p.o.) along chloride. VI standard (750 Results: results showed significantly high levels urinary serum creatinine, urea, calcium, uric acid a decrease magnesium compared control). Treatment mg/kg) restored elevated parameters III–VI II. Ethylene administrations lead production oxidative stress superoxide dismutase, reduced glutathione, catalase activity. Lycopene treatment normal. Histologically, alleviated damaged integrity renal structure. Conclusion: Supplementation (100 mg/kg reduces prevents toxicity caused by administration protects cells damage.